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Fig. 8 | Journal of Neuroinflammation

Fig. 8

From: Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

Fig. 8

Schematic representation of the main findings of this study. GPR120 and GPR40 are expressed in the hypothalamus of mice; GPR120 is expressed predominantly in microglia whereas GPR40 is expressed predominantly in POMC and NPY neurons. The intracerebroventricular (icv) injection of agonists in mice results in a number of phenotypic changes. TUG1197, the GPR120 agonist, acts predominantly reducing hypothalamic inflammation. TUG905, the GPR40 agonist, acts predominantly reducing body mass and increasing the expression of the anorexigenic precursor, POMC. The use of a compound that acts simultaneously on GPR120 and GPR40, GW9508, results in the best metabolic outcomes, reducing body mass, improving glucose tolerance and reducing hypothalamic inflammation

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Journal of Neuroinflammation

ISSN: 1742-2094