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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Kososan, a Kampo medicine, prevents a social avoidance behavior and attenuates neuroinflammation in socially defeated mice

Fig. 6

Kososan extract improved the stress-induced decrease in hippocampal CX3CR1-positive cells in mice. On day 13, CX3CR1 staining was performed using three coronal sections per mouse. a Representative photomicrographs depicting CX3CR1 co-expressed with an Iba1-positive cell (upper panel) and a CX3CR1-positive cell (lower panel) in the DG. The arrow in the lower panel shows a CX3CR1-positive cell in the MOL. Scale bar = 20 μm. b The number of CX3CR1-positive cells in each of the four subregions of the DG is presented. Data are presented as the mean ± SEM (n = 12–15 per group). *p < 0.05, **p < 0.01, and ***p < 0.001 according to Bonferroni’s post hoc test. MOL molecular layer, GCL granular cell layer, SGZ subgranular zone, DG dentate gyrus, KS kososan

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