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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Kososan, a Kampo medicine, prevents a social avoidance behavior and attenuates neuroinflammation in socially defeated mice

Fig. 7

Kososan extract did not improve the stress-induced increase in hippocampal NLRP3-positive cells in mice. On day 13, NLRP3 staining was performed on three coronal brain hemisphere sections per mouse. a Representative photomicrographs depict NLRP3 co-expressed with an Iba1-positive cell (upper panel) and NLRP3-positive cells (lower panel) in the DG. Arrows and arrowhead in the lower panel show NLRP3-positive cells in the SGZ and hilus, respectively. Scale bar = 20 μm. b The number of NLRP3-positive cells in each of the four DG subregions is presented. Data are shown as the mean ± SEM (n = 12–15 per group). *p < 0.001 according to Bonferroni’s post hoc test. MOL molecular layer, GCL granular cell layer, SGZ subgranular zone, DG dentate gyrus, KS kososan

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