Fig. 7

SAH grade and neurological deficits at 24 and 72 h; effect of TXNIP on SAH-induced BBB permeability and brain water content. SAH grading scores showed no statistically significant difference between the surgery and treatment groups (a, n = 6, each group). TXNIP siRNA and RES treatment increased the neurological score when compared with the control group, but GSK2656157 and STF083010 injection showed no significant score improvement (b). BBB disruption was also attenuated in three areas (LH, RH, CB) after treatment with TXNIP siRNA, RES or GSK2656157 (c). However, there were no significant differences between groups in the BS (c). The brain water content of LH, RH and CB was reduced by TXNIP siRNA, RES, GSK2656157 and STF083010 treatment (d, Additional file 5: Table S1). But, there were no statistical differences in BS between each control and treatment groups (d, Additional file 5: Table S1). ^@ p < 0.05 vs. sham. *p < 0.05 vs. SAH+ control siRNA. ^# p < 0.05 vs. SAH + NS. &^/$ p < 0.05 vs. SAH + DMSO. SAH subarachnoid haemorrhage, RES resveratrol, siRNA small interfering RNA, NS normal saline, BBB blood–brain barrier, GSK GSK2656157, STF STF083010, DMSO dimethylsulfoxide, LH left hemisphere, RH right hemisphere, CB cerebellum, BS brain stem