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Table 1 Choroid plexus DEGs between PRNP genotypes after LPS treatment

From: LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface

Gene ID Symbol Gene name Log2 ratio Top functions
100860813 MHC II HA25 1.80 Antigen presentation (extracellular pathway)
102178155 FTSJ1 FtsJ RNA methyltransferase homolog 1 1.53 Methyltransferase
102169982 ISG15 ISG15 ubiquitin-like modifier 0.99 ISGylation, innate immunity
102189650 ANK3 Ankyrin 3 0.75 Cell motility, activation, proliferation,
102187800 UBB Ubiquitin B 0.73 Targeting of proteins for degradation
102184593 SPOCK2 SPARC/osteonectin, cwcv and kazal-like domains proteoglycan 2 0.68 Extracellular matrix structure
102183219 BGN Biglycan −0.60 Extracellular matrix structure, innate immunity
102188061 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit −0.63 Catalyzes ATP synthesis, oxidative phosphorylation
102185420 COL24A1 Collagen type XXIV alpha 1 chain −0.66 Extracellular matrix structure
102172487 CP Ceruloplasmin −0.66 Acute phase protein, ferroxidase enzyme
102169556 CXCL12 C-X-C motif chemokine ligand 12 −0.67 Chemoattractant, innate immunity
102172637 LECT1 Leukocyte cell derived chemotaxin 1 −0.69 Promotes chondrocyte growth, inhibit angiogenesis
102170107 ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex subunit F2 −0.70 Catalyzes ATP synthesis, oxidative phosphorylation
102181355 PCOLCE Procollagen C-endopeptidase enhancer −0.75 Collagen precursor peptidase activator
100860756 OGN Osteoglycin −0.76 Growth factor activity
102179198 TNC Tenascin C −0.81 Extracellular matrix structure
102182694 CXCL14 C-X-C motif chemokine ligand 14 −0.81 Chemoattractant, immunomodulatory
102177419 NDUFA1 NADH:ubiquinone oxidoreductase subunit A1 −0.85 Component of the respiratory chain, mitochondria
102191086 COCH Cochlin −1.03 Extracellular matrix, pro-inflammatory, cytokine regulatory
102187830 COL17A1 Collagen type XVII alpha 1 chain −1.04 Hemidesmosome component
102189939 ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex subunit E −1.58 Catalyze ATP synthesis, oxidative phosphorylation
100860915 ASIP Agouti signaling protein −2.14 Paracrine signaling, pigmentation
102180584 MHC I BOLA class I histocompatibility antigen, alpha chain BL3-7 −2.32 Antigen presentation (cytosolic pathway)
102169975 PRNP Prion protein −2.80 Unknown, cytoprotective
102176354 HP Haptoglobin −3.25 Acute phase protein, bind hemoglobin
  1. Differential expression analysis was performed by comparing LPS-treated PRNP Ter/Ter vs. PRNP +/+ (log2 ratio ± 0.59 and q < 0.05). n = 15