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Table 2 Upregulated and downregulated genes in the hippocampus after LPS challenge

From: LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface

  Log2 ratio, LPS vs. saline  
Gene ID Symbol Gene name PRNP +/+ PRNP Ter/Ter Top functions
102185230 IFI6 Interferon alpha inducible protein 6 1.19* −0.05 Regulation of apoptosis
100860873 CXCL10 C-X-C motif chemokine ligand 10 3.37* 3.07* Chemoattractant
102187851 CXCL9 C-X-C motif chemokine ligand 9 2.93* 2.65* Chemoattractant
102185477 TGM2 Transglutaminase 2 1.25* 1.36* Unclear, involved in phagocytosis
102189939 ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex subunit E 0.53 0.76* Catalyze ATP synthesis
102190069 GFAP Glial fibrillary acidic protein 0.34 0.62* Cell communication, mitosis, BBB function
102178715 HOPX HOP homeobox 0.35 0.65* Unknown
102188072 MT2 Metallothionein-2 0.29 0.91* Metal-binding, neuroprotection
102188618 MT1A Metallothionein-1A 0.58 1.40* Metal-binding, neuroprotection
100860878 SLC14A1 Solute carrier family 14 member 1 0.54 1.59* Membrane transport (urea)
102186073 AQP4 Aquaporin 4 −0.61* −0.31 Membrane transport (water)
102175716 MYO10 Myosin X −0.66* −0.53 Motor molecule, bind actin
102186825 COL9A2 Collagen type IX alpha 2 chain −0.43 −0.64* Extracellular matrix structure
  1. Differential expression analyses were performed by comparing the LPS groups to the saline control group of the matching genotype. Italic values indicate a true differential expression. LPS, n = 15. Saline, n = 10
  2. *log2 ratio ±0.59, q < 0.05