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Table 2 Upregulated and downregulated genes in the hippocampus after LPS challenge

From: LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface

 

Log2 ratio, LPS vs. saline

 

Gene ID

Symbol

Gene name

PRNP +/+

PRNP Ter/Ter

Top functions

102185230

IFI6

Interferon alpha inducible protein 6

1.19*

−0.05

Regulation of apoptosis

100860873

CXCL10

C-X-C motif chemokine ligand 10

3.37*

3.07*

Chemoattractant

102187851

CXCL9

C-X-C motif chemokine ligand 9

2.93*

2.65*

Chemoattractant

102185477

TGM2

Transglutaminase 2

1.25*

1.36*

Unclear, involved in phagocytosis

102189939

ATP5I

ATP synthase, H+ transporting, mitochondrial Fo complex subunit E

0.53

0.76*

Catalyze ATP synthesis

102190069

GFAP

Glial fibrillary acidic protein

0.34

0.62*

Cell communication, mitosis, BBB function

102178715

HOPX

HOP homeobox

0.35

0.65*

Unknown

102188072

MT2

Metallothionein-2

0.29

0.91*

Metal-binding, neuroprotection

102188618

MT1A

Metallothionein-1A

0.58

1.40*

Metal-binding, neuroprotection

100860878

SLC14A1

Solute carrier family 14 member 1

0.54

1.59*

Membrane transport (urea)

102186073

AQP4

Aquaporin 4

−0.61*

−0.31

Membrane transport (water)

102175716

MYO10

Myosin X

−0.66*

−0.53

Motor molecule, bind actin

102186825

COL9A2

Collagen type IX alpha 2 chain

−0.43

−0.64*

Extracellular matrix structure

  1. Differential expression analyses were performed by comparing the LPS groups to the saline control group of the matching genotype. Italic values indicate a true differential expression. LPS, n = 15. Saline, n = 10
  2. *log2 ratio ±0.59, q < 0.05