Fig. 1

RTK inhibitor downregulates cell death associated with B. burgdorferi exposure. Differentiated MO3.13 cells were assessed for cell death via apoptosis and total cell viability in the presence or absence of B. burgdorferi (Bb, MOI 10:1) and 10 μM EGFR/FGFR/PDGFR tyrosine kinase inhibitor. DMSO was added as a solvent control. a TUNEL-positive cells at 48-h post exposure. In b, cell viability as assessed by the MTT assay at 72-h post exposure is shown. Values from a representative experiment are shown in each case (out of three experiments for a and two experiments for b). Bars represent standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001