Receptor tyrosine kinases play a significant role in human oligodendrocyte inflammation and cell death associated with the Lyme disease bacterium Borrelia burgdorferi

Table 2 Average fold change^a in chemokine/cytokine levels in the presence of TLR inhibitors at 48 h

Chemokine-cytokine/treatment	CCL2	CXCL8	CCL5	CXCL(1,2,3)	IL-6
Bb + 20 μg/mL TLR2/4 inhibitor	1.489 (±0.384)	0.456 (±0.043)	0.752 (±0.151)	0.573 (±0.092)	0.915 (±0.092)
Bb + 5 μg/mL TLR4 inhibitor	1.551 (±0.138)	0.915 (±0.050)	3.911 (±0.769)	0.993 (±0.062)	1.016^b (±0.104)

^aFold change was calculated as B. burgdorferi (MOI 10:1) + solvent control/B. burgdorferi + inhibitor for each experiment. In the case of the TLR2/4 inhibitor (OxPAPC), average fold change values were calculated from the mean of two to three independent experiments, while for the TLR4 inhibitor the values were calculated from the mean of three to four independent experiments. Standard error of the mean is indicated within parenthesis. Fold change values >1 indicate a downregulation of chemokine/cytokine levels, and values <1 indicate an increase in those levels. Values in italics or those in bold indicate statistically significant upregulation or downregulation respectively, in a majority (≥67%) of experiments
^bInconclusive results

ISSN: 1742-2094