Receptor tyrosine kinases play a significant role in human oligodendrocyte inflammation and cell death associated with the Lyme disease bacterium Borrelia burgdorferi

Table 3 Average fold change^a in chemokine/cytokine levels in the presence of EGF/FGF/PDGF RTK inhibitor at 48 h

Chemokine-cytokine/treatment	CCL2	CXCL8	CCL5	CXCL(1,2,3)	IL-6
Bb + 10 μM inhibitor	15.097 (±6.803)	3.134 (±0.189)	1.234 (±0.160)	1.415 (±0.162)	1.602 (±0.491)
Bb + 5 μM inhibitor	15.677 (±5.388)	3.270 (±0.672)	1.000 (±0.138)	1.313 (±0.207)	1.562 (±0.456)
Bb + 1 μM inhibitor	4.094 (±0.597)	1.103 (±0.014)	1.432 (±0.268)	0.646 (±0.034)	0.665 (±0.153)

^aFold change was calculated as B. burgdorferi (MOI 10:1) + solvent control/B. burgdorferi + inhibitor for each experiment. Average fold change values were calculated from mean of three independent experiments, with standard error of the mean within parenthesis. Fold change values >1 indicate a downregulation of chemokine/cytokine levels, and values <1 indicate an increase in those levels. Values in italics or those in bold indicate statistically significant upregulation or downregulation respectively, in a majority (>67% or 2/3) of experiments

ISSN: 1742-2094