Table 1 Normalized Cytokines and Chemokines Expression in Detached Retinas
RD 1 day (Mean ± SD) | RD 7 days (Mean ± SD) | |||||||
|---|---|---|---|---|---|---|---|---|
Untreated (n = 6) | Anti-IL6Rα (n = 6) | Anti-gp130 (n = 6) | IL6 KO (n = 6) | Untreated (n = 8) | Anti-IL6Rα (n = 6) | Anti-gp130 (n = 8) | IL6 KO (n = 6) | |
CXCL1 | 1.2 ± 0.7 | 1.2 ± 0.3 | 0.9 ± 0.3 | 0.7 ± 0.1 | 0.5 ± 0.1 | 0.3 ± 0.2 | 0.6 ± 0.4 | 0.6 ± 0.3 |
CXCL2 | 1.3 ± 1.3 | 0.6 ± 0.1 | 0.3 ± 0.1 | 0.1 ± 0.0 | 0.2 ± 0.2 | 0.2 ± 0.1 | 0.3 ± 0.2 | 0.2 ± 0.1 |
CXCL9 | 0.6 ± 0.4 | 1.3 ± 0.5 | 0.6 ± 0.5 | 0.3 ± 0.1 | 0.4 ± 0.4 | 0.4 ± 0.2 | 0.4 ± 0.2 | 0.2 ± 0.1 |
CXCL10 | 1.2 ± 0.5 | 1.7 ± 0.4 | 1.1 ± 0.3 | 0.7 ± 0.2 | 0.7 ± 0.3 | 0.9 ± 0.9 | 0.7 ± 0.5 | 0.4 ± 0.2 |
CXCL11 | 0.6 ± 0.3 | 1.0 ± 0.4 | 0.6 ± 0.2 | 0.4 ± 0.1 | 0.4 ± 0.2 | 0.3 ± 0.1 | 0.4 ± 0.3 | 0.3 ± 0.2 |
CXCL12 | 0.8 ± 0.1 | 0.9 ± 0.3 | 0.9 ± 0.2 | 0.7 ± 0.2 | 0.6 ± 0.3 | 0.5 ± 0.2 | 0.7 ± 0.3 | 0.9 ± 0.1 |
CXCL13 | 1.0 ± 0.5 | 1.0 ± 0.2 | 1.0 ± 0.1 | 0.8 ± 0.2 | 0.5 ± 0.1 | 0.4 ± 0.1 | 0.6 ± 0.4 | 0.5 ± 0.2 |
CCL1 | 0.6 ± 0.3 | 0.8 ± 0.2 | 0.8 ± 0.1 | 1.0 ± 0.1 | 0.5 ± 0.2 | 0.4 ± 0.1 | 0.6 ± 0.3 | 0.6 ± 0.0 |
CCL2 | 15.1 ± 6.9 | 4.4 ± 0.7* | 1.7 ± 1.0** | 1.2 ± 0.4** | 0.7 ± 0.4 | 1.0 ± 0.8 | 0.6 ± 0.3 | 0.5 ± 0.1 |
CCL3 | 1.5 ± 1.3 | 1.5 ± 0.6 | 0.7 ± 0.5 | 0.3 ± 0.1 | 0.3 ± 0.2 | 0.3 ± 0.1 | 0.4 ± 0.2 | 0.4 ± 0.2 |
CCL4 | 0.8 ± 0.2 | 0.7 ± 0.1 | 0.7 ± 0.1 | 0.8 ± 0.1 | 0.5 ± 0.2 | 0.3 ± 0.1 | 0.6 ± 0.3 | 0.8 ± 0.1 |
CCL5 | 1.7 ± 1.4 | 2.1 ± 0.7 | 1.1 ± 0.5 | 0.9 ± 0.2 | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.5 ± 0.1 | 0.7 ± 0.1 |
CCL11 | 0.6 ± 0.2 | 0.8 ± 0.1 | 0.8 ± 0.2 | 0.5 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.0 | 0.5 ± 0.3 | 0.5 ± 0.1 |
CCL12 | 1.1 ± 0.5 | 1.3 ± 0.3 | 1.0 ± 0.5 | 0.7 ± 0.1 | 0.6 ± 0.1 | 0.5 ± 0.2 | 0.6 ± 0.3 | 0.6 ± 0.4 |
CCL17 | 0.8 ± 0.4 | 0.8 ± 0.1 | 1.2 ± 0.3 | 1.4 ± 0.2 | 0.5 ± 0.2 | 0.3 ± 0.0 | 0.6 ± 0.4 | 0.5 ± 0.4 |
IL-1α | 0.8 ± 0.1 | 0.7 ± 0.1 | 1.0 ± 0.1 | 0.7 ± 0.1 | 0.5 ± 0.2 | 0.5 ± 0.4 | 0.8 ± 0.3 | 1.0 ± 0.1 |
IL-1β | 0.7 ± 0.4 | 1.0 ± 0.5 | 0.6 ± 0.4 | 0.2 ± 0.1 | 0.4 ± 0.2 | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.1 |
IL-1ra | 1.9 ± 1.9 | 1.5 ± 0.2 | 0.7 ± 0.5 | 0.5 ± 0.2 | 0.6 ± 0.2 | 0.7 ± 0.4 | 0.6 ± 0.2 | 0.6 ± 0.1 |
IL2 | 0.6 ± 0.1 | 0.6 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.2 | 0.6 ± 0.3 | 0.4 ± 0.3 | 0.5 ± 0.2 | 0.7 ± 0.1 |
IL-3 | 0.8 ± 0.3 | 1.5 ± 0.1 | 0.8 ± 0.4 | 0.6 ± 0.2 | 0.4 ± 0.2 | 0.3 ± 0.2 | 0.5 ± 0.4 | 0.4 ± 0.4 |
IL-4 | 0.8 ± 0.5 | 1.2 ± 0.3 | 0.6 ± 0.3 | 0.3 ± 0.1 | 0.3 ± 0.3 | 0.3 ± 0.2 | 0.3 ± 0.2 | 0.2 ± 0.2 |
IL-5 | 0.5 ± 0.3 | 0.8 ± 0.2 | 0.7 ± 0.2 | 0.7 ± 0.1 | 0.5 ± 0.2 | 0.3 ± 0.2 | 0.4 ± 0.3 | 0.4 ± 0.2 |
IL-6 | 0.6 ± 0.2 | 0.8 ± 0.1 | 0.8 ± 0.2 | 0.8 ± 0.2 | 0.5 ± 0.1 | 0.3 ± 0.1 | 0.7 ± 0.5 | 0.6 ± 0.5 |
IL-7 | 0.6 ± 0.4 | 0.9 ± 0.3 | 0.6 ± 0.2 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.4 ± 0.3 | 0.3 ± 0.1 |
IL-10 | 0.6 ± 0.2 | 0.7 ± 0.0 | 0.6 ± 0.1 | 0.8 ± 0.2 | 0.3 ± 0.0 | 0.3 ± 0.0 | 0.4 ± 0.1 | 0.5 ± 0.0 |
IL-13 | 0.7 ± 0.5 | 1.4 ± 0.6 | 0.6 ± 0.4 | 0.2 ± 0.0 | 0.3 ± 0.2 | 0.3 ± 0.1 | 0.3 ± 0.2 | 0.3 ± 0.0 |
IL-12 p70 | 0.5 ± 0.1 | 0.7 ± 0.1 | 0.7 ± 0.2 | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.3 ± 0.1 | 0.5 ± 0.4 | 0.5 ± 0.2 |
IL-16 | 0.9 ± 0.6 | 0.6 ± 0.0 | 0.7 ± 0.1 | 0.6 ± 0.1 | 0.4 ± 0.1 | 0.3 ± 0.0 | 0.7 ± 0.5 | 0.6 ± 0.4 |
IL-17 | 0.4 ± 0.3 | 0.6 ± 0.2 | 0.4 ± 0.2 | 0.2 ± 0.1 | 0.2 ± 0.2 | 0.2 ± 0.1 | 0.3 ± 0.3 | 0.3 ± 0.1 |
IL-23 | 0.6 ± 0.2 | 0.8 ± 0.1 | 0.6 ± 0.3 | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.4 ± 0.1 | 0.5 ± 0.2 | 0.5 ± 0.1 |
IL-27 | 0.8 ± 0.5 | 1.6 ± 0.5 | 0.6 ± 0.7 | 0.2 ± 0.1 | 0.3 ± 0.2 | 0.4 ± 0.1 | 0.4 ± 0.2 | 0.3 ± 0.2 |
G-CSF | 0.6 ± 0.4 | 1.1 ± 0.3 | 0.9 ± 0.3 | 0.6 ± 0.0 | 0.4 ± 0.0 | 0.3 ± 0.1 | 0.5 ± 0.2 | 0.4 ± 0.1 |
GM-CSF | 0.6 ± 0.3 | 0.9 ± 0.2 | 1.0 ± 0.2 | 0.9 ± 0.1 | 0.5 ± 0.2 | 0.3 ± 0.0 | 0.7 ± 0.3 | 0.6 ± 0.3 |
M-CSF | 0.9 ± 0.5 | 1.6 ± 0.3 | 0.9 ± 0.8 | 0.3 ± 0.1 | 0.5 ± 0.3 | 0.5 ± 0.3 | 0.6 ± 0.4 | 0.4 ± 0.4 |
sICAM-1 | 2.3 ± 0.7 | 2.3 ± 0.3 | 2.2 ± 0.3 | 1.8 ± 1.0 | 2.7 ± 0.1 | 2.6 ± 0.5 | 2.3 ± 0.4 | 2.0 ± 0.6 |
IFN-γ | 0.7 ± 0.4 | 1.3 ± 0.8 | 0.7 ± 0.4 | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.3 ± 0.1 | 0.4 ± 0.2 | 0.6 ± 0.1 |
TIMP-1 | 3.9 ± 3.9 | 3.6 ± 1.1 | 1.3 ± 1.5 | 0.5 ± 0.2* | 1.2 ± 1.6 | 1.6 ± 1.9 | 0.9 ± 0.7 | 0.6 ± 0.7 |
TNF-a | 0.6 ± 0.3 | 0.8 ± 0.2 | 0.9 ± 0.2 | 1.1 ± 0.0 | 0.6 ± 0.3 | 0.5 ± 0.2 | 0.8 ± 0.3 | 0.9 ± 0.1 |
TREM-1 | 1.3 ± 0.7 | 2.1 ± 0.6 | 0.9 ± 0.6 | 0.5 ± 0.0 | 0.5 ± 0.3 | 0.5 ± 0.2 | 0.5 ± 0.2 | 0.4 ± 0.1 |
C5/C5a | 0.6 ± 0.4 | 0.8 ± 0.2 | 0.5 ± 0.3 | 0.4 ± 0.1 | 0.2 ± 0.1 | 0.2 ± 0.1 | 0.4 ± 0.3 | 0.2 ± 0.3 |