Fig. 5
From: Acute neuroinflammation induces AIS structural plasticity in a NOX2-dependent manner
Ablation of NOX2-derived ROS production prevents AIS disruption. a–f AISs in layer V of the cerebral cortex from NOX2+/+ (a–c) and NOX2−/− (d–f) mice are identified by ankG immunolabeling after saline (a, d) or LPS (b, c, e, f) treatment. AISs are lost in LPS-treated NOX2+/+ mice, but are preserved in LPS-treated NOX2−/− mice. Scale bar = 20 μM. g The mean ± SEM of AISs/FOV in NOX2+/+ and NOX2−/− mice treated with saline or LPS as a percent of saline controls. An asterisk indicates significant difference (p < 0.05) from saline, and a ¥ indicates a difference between genotypes