Table 1 Immunological Comparisons between multiple sclerosis and myasthenia gravis

Similarities

↑ Th1 and Th17 cells [24]

↑ IL-1, -6, -17, IFN-γ, and TNF-α [26]

Treg-related genetic polymorphisms (IL-2 signaling, CD25, CD127) [55]

↓ Recent thymic emigrants in blood [29, 32]

↑ CXCR5 expression, correlates with disease [34]

Clonally expanded B cells in thymus [33]

↓ Tr1 and IL-10 [27]

↑ Fas expression on Tregs [104]

↑ Th1 and Th17 cells [23]

↑ IL-1, -6, -17, IFN-γ, and TNF-α [23, 25]

Treg-related genetic polymorphisms [56]

↓ Recent thymic emigrants in blood [28]

↑ CXCR5 expression, correlates with disease [34]

Clonally expanded B cells in thymus [33]

↓ Expression of FoxP3 and IL-10 on Tregs [28]

↑ Fas expression on Tregs [13]

Differences

Thymectomy not beneficial [31]

Macrophage cell-mediated damage [96]

Can be treated via IFN-1 (beta) [12]

Thymectomy Beneficial [197]

Antibody-mediated damage [39]

Can be induced via IFN-1 (alpha) [42]