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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Evidence for an early innate immune response in the motor cortex of ALS

Fig. 3

MCP1+ and CCR2+ cells are visualized in motor cortex and spinal cord of MCP1-CCR2-hSOD1G93A mice. a, b Representative images of MCP1+ and CCR2+ cells with no immunohistochemistry enhancement for mRFP or eGFP. Very few cells are present in the motor cortex of MCP1-CCR2-WT mice. Insets enlarged to the right (a’, b’). ch Representative images of MCP1+ and CCR2+ cells with no immunohistochemistry enhancement for mRFP or eGFP. Number of cells are present vary at different stages of disease initiation and progression throughout the motor cortex in MCP1-CCR2-hSOD1G93A mice. Insets enlarged to the right (c’h”). i Representative images of MCP1+ and CCR2+ cells with no immunohistochemistry enhancement for mRFP or eGFP. Cells are noticeable around the meninges surrounding the cingulate cortex in MCP1-CCR2-hSOD1G93A mice. Insets enlarged to the right (jn). o Representative images of MCP1+ and CCR2+ cells with no immunohistochemistry enhancement for mRFP or eGFP. Few cells are present in the ventral horn of the MCP1-CCR2-WT mice spinal cord. Inset enlarged to the right (o’). p Representative images of MCP1+ and CCR2+ cells with no immunohistochemistry enhancement for mRFP or eGFP. Numerous cells are present in MCP1-CCR2-hSOD1G93A mice at the end stage. Insets enlarged to the right (p’p”’). MCP1+ and CCR2+ cells do not co-localize with neuronal marker (Map2) in the motor cortex or spinal cord

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