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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Evidence for an early innate immune response in the motor cortex of ALS

Fig. 6

MCP1+ cells are detected early in the motor cortex of MCP1-CCR2-hSOD1G93A mice. a-e Representative drawings showing the relative location of MCP1+ cells in the motor cortex, somatosensory cortex, striatum, hippocampus, and cingulate cortex within the five brain sections studied. f-h Graphs represent average number of MCP1+ cells per area of interest ± SEM in MCP1-CCR2-WT mice (blue columns) and MCP1-CCR2-hSOD1G93A mice (red column) at the pre-symptomatic (P30), early symptomatic (P60), symptomatic (P90), and end stage (P120). Increased numbers of MCP1+ cells are detected in the primary motor cortex of MCP1-CCR2-hSOD1G93A mice as early as P30. Abbreviations: MCtx motor cortex, SCtx somatosensory cortex, Str striatum, Hippo hippocampus, CgCtx cingulate cortex. *p < 0.05, **p < 0.01, ***p < 0.01; MCP1-CCR2-WT mice vs. MCP1-CCR2-hSOD1G93A mice

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