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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Sac-1004, a vascular leakage blocker, reduces cerebral ischemia—reperfusion injury by suppressing blood–brain barrier disruption and inflammation

Fig. 7

Sac-1004 inhibits glial activation after I/R. Immunofluorescence staining (a, b) of CD11b and GFAP in the ischemic cortex of the sham, vehicle-ischemia, and Sac-1004-ischemia groups 3 h after I/R. Profound expression of CD11b and GFAP was observed in the vehicle-ischemia group compared with that in the sham group, whereas the Sac-1004-ischemia group showed reduced expression of CD11b and GFAP. Scale bar = 50 μm. Glial activation(c, d) is quantified by the intensity of CD11b and GFAP immunofluorescence (n = 5 per group; ** P < 0.01 and *** P < 0.001 vs sham group, ## P < 0.01 and ### P < 0.001 vs vehicle-ischemia group). The bars indicate the means ± SEM

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