Fig. 6

Correlation of the cerebrospinal fluid albumin concentration and albumin quotient with the serum MIF concentration. Correlation between the concentration of albumin in the cerebrospinal fluid (CSF) expressed in mg/dl or of the CSF albumin quotient (AQ) on admission to hospital (vertical axis) and the simultaneous concentration of MIF in serum or CSF expressed in pg/ml (horizontal axis). a Concentration of MIF in serum obtained on admission to hospital from 33 TBE patients and CSF albumin concentration. Filled squares denote patients with meningitis (M), empty circles patients with meningoencephalitis (ME), a circle with a cross in a—a patient with meningoencephalomyelitis (MEM). The arrow show data points representing one patient with M and two with ME who were excluded from the analyses presented, respectively, in b, c. b The same as in a, in a subgroup of meningitis patients, the outlying data from one patient were removed. Positive correlation with p < 0.03. c The same as in a, but the outlying data from one patient with meningitis and two with meningoencephalitis were removed. Positive correlation with p < 0.01. d The same as b, but with AQ*100 instead of the CSF albumin concentration. Positive correlation with p < 0.05. e The same as c, with AQ*100 instead of the CSF albumin concentration. The trend for a positive correlation did not reach the level of statistical significance. f Concentration of MIF in CSF on admission in a group of five TBE patients: left—a strong positive correlation with CSF albumin concentration (p < 0.05), right—a tendency for a positive correlation with AQ. Filled squares denote patients with meningitis and an empty circle a patient with meningoencephalitis as in a. g Concentration of MIF in six patients with non-TBEV neuroinfection, in serum (left) and in CSF (right), did not correlate with CSF albumin concentration. Diamonds—patients with mild meningitis hospitalized during Echovirus 30 outbreak; circle—patient with a moderately severe meningoencephalitis of unknown etiology. The same results were obtained for AQ instead of CSF albumin concentration (not shown)