Fig. 1

PAR1 and IL-1 receptor surface expression in human brain tissue. a Immunohistochemistry for PAR1 demonstrates a low level of baseline staining in healthy human brain tissue. b There is more prominent PAR1 staining within MS brain tissue. c IL-1 receptor staining in healthy tissue and d around a demyelinated plaque were similar. e Luxol fast blue stain shows a demyelinated region and subsequent images show PAR1 staining is pronounced within a lesion’s borders and follows a gradient diminishing at approach to the lesion’s outermost border. f Within demyelinated lesions there are darkly stained PAR1-positive neurons with visible unmyelinated axons (arrows). Bars = 50 μm