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Table 2 Neuronal density in brain tissue from patients with MS or control patients

From: Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β

Density (neurons/mm2) Control cortex MS cortex MS lesion Significance
Total number 65.3 ± 3.9 55.6 ± 2.1* 46.6 ± 8.2** *p < 0.01, ** p < 0.001
PAR1 high expression 29.0 ± 4.2 37.7 ± 2.8* 44.3 ± 6.8* *p < 0.01
IL-1 receptor low expression 58.9 ± 1.1 59.2 ± 1.3 58.1 ± 1.4 NS
  1. Data are mean ± standard error of the mean