Protease-activated receptor-1 activation by granzyme B causes neurotoxicity that is augmented by interleukin-1β

Table 2 Neuronal density in brain tissue from patients with MS or control patients

Density (neurons/mm²)	Control cortex	MS cortex	MS lesion	Significance
Total number	65.3 ± 3.9	55.6 ± 2.1*	46.6 ± 8.2**	p < 0.01, * p < 0.001
PAR1 high expression	29.0 ± 4.2	37.7 ± 2.8*	44.3 ± 6.8*	*p < 0.01
IL-1 receptor low expression	58.9 ± 1.1	59.2 ± 1.3	58.1 ± 1.4	NS

ISSN: 1742-2094