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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Interleukin-1 receptor type 1 is overexpressed in neurons but not in glial cells within the rat superficial spinal dorsal horn in complete Freund adjuvant-induced inflammatory pain

Fig. 4

Mechanical withdrawal threshold and thermal withdrawal latency of wild type and IL-1R1 knockout mice during the course of CFA-induced inflammation of the hind paw. a The histogram shows the mechanical withdrawal threshold (MWT) of wild type (BL6) and IL-1R1 knockout (IL-1R1 KO) mice receiving different treatments in the three experimental groups: group (1) complete Freund-adjuvant (CFA) injection (BL6 CFA, IL-1R1 KO CFA); group (2) physiological saline injection (BL6 sham, IL-1R1 KO sham); and group (3) without any treatment (BL6 control, IL-1R1 KO control). Measurements were made only on the right hind paw which received the physiological saline or CFA injections. b The histogram shows the thermal withdrawal latency (TWL) of wild type (BL6) and IL-1R1 knockout (IL-1R1 KO) mice receiving different treatments in the three experimental groups: group (1) complet Freund-adjuvant (CFA) injection (BL6 CFA, IL-1R1 KO CFA); group (2) physiological salt solution injection (BL6 sham, IL-1R1 KO sham); and group (3) without any treatment (BL6 control, IL-1R1 KO control). Measurements were made only on the right hind paw which received the physiological saline or CFA injections. Data are shown as mean ± SEM

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Journal of Neuroinflammation

ISSN: 1742-2094