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Table 2 List of genes that showed statistically significant changes in tissue samples obtained from the spinal dorsal horn of CFA-injected animals ipsilateral to the CFA injection at post-injection day 3 (at the peak of mechanical allodynia)

From: Interleukin-1 receptor type 1 is overexpressed in neurons but not in glial cells within the rat superficial spinal dorsal horn in complete Freund adjuvant-induced inflammatory pain

Gene symbol

Gene name

ΔCt control

ΔCt treated

Fold change 2-ΔΔCt

p value

Faah

fatty acid amid hydrolase

6.4 ± 0.01

6.7 ± 0.1

0.78

0.0368

Gria2

ionotropic glutamate receptor, AMPA2

3.0 ± 0.24

3.3 ± 0.06

0.77

0.0447

il1r1

interleukin 1 receptor 1

14.7 ± 0.001

12.1 ± 0.002

6.02

0.0002

Nape-pld

N-acyl-phosphatidylethanolamine-hydrolising phospholipase D

7.0 ± 0.06

6.9 ± 0.17

1.11

0.0016

  1. Values obtained from CFA-injected animals were compared to values obtained from control animals. Note that we observed a highly significant, approximately six times increase in the quantity of IL-1R1 receptor mRNA in the experimental animals