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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: The role of microglial P2X7: modulation of cell death and cytokine release

Fig. 5

Cytokine secretion by WT and P2X7−/− microglia under pro- and anti-inflammatory conditions. Microglia from WT and P2X7−/− mice were treated with 100 ng/ml LPS, 100 ng/ml LPS plus 10 ng/ml IFNγ, or 10 ng/ml IL4 plus 10 ng/ml IL13 for 22 h in the presence or absence of 380 μM BzATP for additional 2 h. ad The secretion of IL1β from WT microglia (a) and P2X7−/− microglia (b), as well as IL18 release from WT microglia (c) and P2X7−/− microglia (d) was assessed by ELISA. Data are shown as mean + SD of triplicates. Experiment repeated twice independently. One-way ANOVA followed by Tukey’s post hoc test. ***P < 0.001; ****P < 0.0001

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