CXCL11 production in cerebrospinal fluid distinguishes herpes simplex meningitis from herpes simplex encephalitis

Lind, Liza; Studahl, Marie; Persson Berg, Linn; Eriksson, Kristina

doi:10.1186/s12974-017-0907-5

Journal of Neuroinflammation

Table 2 Levels of chemokines and cytokines in cerebrospinal fluid of HSE and HSM patients and healthy controls

From: CXCL11 production in cerebrospinal fluid distinguishes herpes simplex meningitis from herpes simplex encephalitis

	CSF-median and range (pg/ml)						p HSE vs. control	p HSM vs. control	p HSE vs. HSM
Cytokine	HSE		HSM		Control
CCL1	31	5–141	21	15–29	17	3–34	0.0032	0.41	0.63
CCL2	186	23–1179	233	41–1565	141	101–215	>0.99	0.19	0.62
CCL3	10	2–15	12	9–27	1	1–2	<0.0001	0.0001	>0.99
CCL7	13	3–42	35	16–57	4	1–8	0.0020	<0.0001	0.27
CCL8	63	4–560	1085	117–8734	5	2–9	0.0012	<0.0001	0.26
CCL11	20	5–41	26	16–36	16	5–22	0.012	0.0007	0.87
CCL13	3	1–15	14	7–105	1	0–2	0.094	<0.0001	0.041
CCL15	264	87–673	378	230–710	123	66–232	0.011	0.0003	0.61
CCL17	21	0–83	15	11–42	2	0–20	0.0001	0.0015	>0.99
CCL19	104	7–339	97	9–259	16	3–69	<0.0001	<0.0001	>0.99
CCL20	1	0–3	3	0–14	0	0–1	0.014	<0.0001	0.50
CCL21	234	58–1369	341	17–822	431	214–1745	0.011	0.025	>0.99
CCL22	34	3–123	38	16–74	9	0–27	0.0017	0.0009	>0.99
CCL23	20	3–126	14	10–27	4	2–10	<0.0001	0.0009	>0.99
CCL24	7	0–19	10	4–17	0	0–6	0.0069	0.0001	0.59
CCL25	91	38–174	139	104–199	51	29–72	0.0019	<0.0001	0.27
CCL26	4	1–16	7	3–10	3	1–5	0.43	0.0024	0.17
CCL27	5	2–11	8	4–16	6	1–13	>0.99	0.21	0.22
CX3CL1	183	71–296	186	38–1016	107	38–289	0.018	0.0011	>0.99
CXCL1	42	21–669	101	9–837	16	5–24	<0.0001	<0.0001	>0.99
CXCL2	7	2–17	11	5–16	4	0–8	0.018	<0.0001	0.32
CXCL5	179	58–461	334	204–708	91	41–346	0.065	0.0002	0.23
CXCL6	4	0–17	8	4–91	0	0–1	0.0004	<0.0001	0.56
CXCL8	102	21–3450	759	24–7130	27	11–77	0.0006	<0.0001	0.30
CXCL9	1877	22–8429	2711	9–11035	19	5–146	<0.0001	<0.0001	>0.99
CXCL10	4508	78–19596	6905	108–27737	125	30–578	<0.0001	<0.0001	>0.99
CXCL11	250	10–3220	6789	2214–9424	42	4–171	0.034	<0.0001	0.047
CXCL12	740	342–1414	423	64–1839	542	213–1708	>0.99	0.80	0.35
CXCL13	16	2–34	5	1–26	1	0–4	<0.0001	<0.0001	0.21
CXCL16	453	326–748	357	159–395	548	437–615	0.32	<0.0001	0.027
GM-CSF	12	0–16	25	10–34	1	0–10	0.037	<0.0001	0.10
IFN-γ	1	0–8	8	4–19	0	0–1	0.13	<0.0001	0.13
IL-1β	3	1–5	7	3–12	1	1–2	0.0025	<0.0001	0.17
IL-2	2	0–3	15	5–29	0	0–1	0.0020	<0.0001	0.12
IL-4	2	1–5	3	1–3	2	0–7	>0.99	>0.99	0.89
IL-6	133	4–2629	1192	123–3627	3	2–11	0.0006	<0.0001	0.35
IL-10	17	4–47	46	16–129	4	2–7	0.0012	<0.0001	0.31
IL-16	73	15–325	156	77–233	24	6–39	0.014	0.0001	0.39
MIF	1303	129–17013	4675	794–7144	666	254–2733	0.35	0.0009	0.12
TNF-α	29	7–74	48	28–63	9	2–16	0.0006	<0.0001	0.52

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