Skip to main content

Table 2 Levels of chemokines and cytokines in cerebrospinal fluid of HSE and HSM patients and healthy controls

From: CXCL11 production in cerebrospinal fluid distinguishes herpes simplex meningitis from herpes simplex encephalitis

  CSF-median and range (pg/ml) p HSE vs. control p HSM vs. control p HSE vs. HSM
Cytokine HSE HSM Control    
CCL1 31 5–141 21 15–29 17 3–34 0.0032 0.41 0.63
CCL2 186 23–1179 233 41–1565 141 101–215 >0.99 0.19 0.62
CCL3 10 2–15 12 9–27 1 1–2 <0.0001 0.0001 >0.99
CCL7 13 3–42 35 16–57 4 1–8 0.0020 <0.0001 0.27
CCL8 63 4–560 1085 117–8734 5 2–9 0.0012 <0.0001 0.26
CCL11 20 5–41 26 16–36 16 5–22 0.012 0.0007 0.87
CCL13 3 1–15 14 7–105 1 0–2 0.094 <0.0001 0.041
CCL15 264 87–673 378 230–710 123 66–232 0.011 0.0003 0.61
CCL17 21 0–83 15 11–42 2 0–20 0.0001 0.0015 >0.99
CCL19 104 7–339 97 9–259 16 3–69 <0.0001 <0.0001 >0.99
CCL20 1 0–3 3 0–14 0 0–1 0.014 <0.0001 0.50
CCL21 234 58–1369 341 17–822 431 214–1745 0.011 0.025 >0.99
CCL22 34 3–123 38 16–74 9 0–27 0.0017 0.0009 >0.99
CCL23 20 3–126 14 10–27 4 2–10 <0.0001 0.0009 >0.99
CCL24 7 0–19 10 4–17 0 0–6 0.0069 0.0001 0.59
CCL25 91 38–174 139 104–199 51 29–72 0.0019 <0.0001 0.27
CCL26 4 1–16 7 3–10 3 1–5 0.43 0.0024 0.17
CCL27 5 2–11 8 4–16 6 1–13 >0.99 0.21 0.22
CX3CL1 183 71–296 186 38–1016 107 38–289 0.018 0.0011 >0.99
CXCL1 42 21–669 101 9–837 16 5–24 <0.0001 <0.0001 >0.99
CXCL2 7 2–17 11 5–16 4 0–8 0.018 <0.0001 0.32
CXCL5 179 58–461 334 204–708 91 41–346 0.065 0.0002 0.23
CXCL6 4 0–17 8 4–91 0 0–1 0.0004 <0.0001 0.56
CXCL8 102 21–3450 759 24–7130 27 11–77 0.0006 <0.0001 0.30
CXCL9 1877 22–8429 2711 9–11035 19 5–146 <0.0001 <0.0001 >0.99
CXCL10 4508 78–19596 6905 108–27737 125 30–578 <0.0001 <0.0001 >0.99
CXCL11 250 10–3220 6789 2214–9424 42 4–171 0.034 <0.0001 0.047
CXCL12 740 342–1414 423 64–1839 542 213–1708 >0.99 0.80 0.35
CXCL13 16 2–34 5 1–26 1 0–4 <0.0001 <0.0001 0.21
CXCL16 453 326–748 357 159–395 548 437–615 0.32 <0.0001 0.027
GM-CSF 12 0–16 25 10–34 1 0–10 0.037 <0.0001 0.10
IFN-γ 1 0–8 8 4–19 0 0–1 0.13 <0.0001 0.13
IL-1β 3 1–5 7 3–12 1 1–2 0.0025 <0.0001 0.17
IL-2 2 0–3 15 5–29 0 0–1 0.0020 <0.0001 0.12
IL-4 2 1–5 3 1–3 2 0–7 >0.99 >0.99 0.89
IL-6 133 4–2629 1192 123–3627 3 2–11 0.0006 <0.0001 0.35
IL-10 17 4–47 46 16–129 4 2–7 0.0012 <0.0001 0.31
IL-16 73 15–325 156 77–233 24 6–39 0.014 0.0001 0.39
MIF 1303 129–17013 4675 794–7144 666 254–2733 0.35 0.0009 0.12
TNF-α 29 7–74 48 28–63 9 2–16 0.0006 <0.0001 0.52