CXCL11 production in cerebrospinal fluid distinguishes herpes simplex meningitis from herpes simplex encephalitis

Lind, Liza; Studahl, Marie; Persson Berg, Linn; Eriksson, Kristina

doi:10.1186/s12974-017-0907-5

Journal of Neuroinflammation

Table 3 Comparison of chemokines and cytokines, including correlations, in CSF and serum of HSE and HSM patients

From: CXCL11 production in cerebrospinal fluid distinguishes herpes simplex meningitis from herpes simplex encephalitis

	Factor CSF/serum		p CSF vs. serum		Correlation HSE		Correlation HSM
Cytokine	HSE	HSM	HSE	HSM	r	p	r	p
CCL1	0.5	0.4	0.016	0.0078	0.3	0.50	0.4	0.30
CCL2	3	5	0.016	0.0078	−0.5	0.20	−0.4	0.36
CCL3	1	2	0.15	0.0078	0.2	0.66	0.4	0.39
CCL7	0.2	0.7	0.023	0.055	−0.6	0.15	0.8	0.015
CCL8	0.7	23	0.74	0.0078	−0.2	0.66	−0.1	0.75
CCL11	0.1	0.2	0.0078	0.0078	0.3	0.50	0.3	0.50
CCL13	0.03	0.2	0.0078	0.039	−0.1	0.84	0.1	0.88
CCL15	0.05	0.1	0.0078	0.0078	0.5	0.27	0.1	0.79
CCL17	0.1	0.2	0.0078	0.0078	0.2	0.66	−0.1	0.79
CCL19	0.3	0.4	0.039	0.11	−0.1	0.84	0.7	0.069
CCL20	0.07	0.5	0.0078	0.023	0.0	0.93	0.7	0.070
CCL21	0.1	0.2	0.0078	0.0078	0.4	0.30	0.3	0.43
CCL22	0.09	0.05	0.0078	0.0078	0.1	0.79	0.2	0.66
CCL23	0.05	0.04	0.0078	0.0078	0.2	0.70	−0.1	0.87
CCL24	0.03	0.04	0.0078	0.0078	0.5	0.24	0.8	0.028
CCL25	0.1	0.3	0.0078	0.0078	−0.3	0.54	0.3	0.54
CCL26	0.2	0.3	0.0078	0.0078	0.2	0.70	0.5	0.24
CCL27	0.01	0.01	0.0078	0.0078	0.0	0.93	0.1	0.88
CX3CL1	0.7	0.8	0.016	0.15	0.1	0.75	0.5	0.22
CXCL1	0.2	0.6	0.31	0.25	−0.5	0.20	0.3	0.50
CXCL2	0.01	0.03	0.0078	0.0078	−0.3	0.46	0.5	0.26
CXCL5	0.1	0.4	0.0078	0.016	−0.1	0.75	0.2	0.70
CXCL6	0.1	0.2	0.0078	0.11	−0.8	0.022	0.5	0.20
CXCL8	3	40	0.0078	0.0078	−0.5	0.27	0.6	0.12
CXCL9	4	12	0.023	0.0078	0.7	0.046	−0.02	0.98
CXCL10	64	66	0.0078	0.0078	0.5	0.27	−0.05	0.93
CXCL11	0.4	31	>0.99	0.0078	0.1	0.75	0.1	0.79
CXCL12	0.9	0.6	0.84	0.055	0.5	0.24	−0.1	0.75
CXCL13	0.7	0.2	0.055	0.0078	0.8	0.037	0.1	0.79
CXCL16	0.7	0.7	0.20	0.023	−0.9	0.011	0.6	0.15
GM-CSF	n/a	n/a	0.039	0.55	0.2	0.66	0.5	0.17
IFN-γ	n/a	n/a	0.38	0.0078	−0.6	0.10	−0.1	0.84
IL-1β	n/a	n/a	0.0078	0.0078	−0.4	0.33	0.6	0.13
IL-2	n/a	n/a	0.023	0.016	−0.6	0.10	−0.01	0.99
IL-4	n/a	n/a	0.0078	0.0078	−0.6	0.12	0.5	0.27
IL-6	n/a	n/a	0.078	0.0078	−0.7	0.058	0.4	0.28
IL-10	n/a	n/a	0.055	0.64	−0.7	0.046	−0.1	0.88
IL-16	n/a	n/a	0.31	0.15	−0.7	0.046	−0.1	0.79
MIF	n/a	n/a	0.25	0.016	0.2	0.66	−0.1	0.84
TNF-α	n/a	n/a	0.55	0.0078	−0.5	0.24	0.6	0.15

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