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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Adaptive lymphocyte profiles correlate to brain Aβ burden in patients with mild cognitive impairment

Fig. 3

B cells shift from the periphery to the CSF as amyloid burden increases. a Soluble IgG in the cerebrospinal fluid (CSF) declines with loss of soluble CSF Aβ42. b Increased mean standardized uptake value ratio (SUVR) for the total cortex correlates to an increase in memory B cell percent representation in the CSF, while c increased Aβ deposition in the precuneous cortex associates with a decline in B cell representation in the peripheral blood. d Soluble Aβ42 in the cerebrospinal fluid (CSF) is decreased in APOε4+ subjects. e, f Apoε4 carriers exhibit enhanced memory B cell percent representation in the CSF, but genotype did not affect overall B cell distribution

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