Fig. 10
From: Chronic glucocorticoid exposure activates BK-NLRP1 signal involving in hippocampal neuron damage
The scheme of the chronic GC exposure increases NLRP1 inflammasome via activation of BK channel. Chronic GC exposure activates NLRP1 inflammasome by upregulation and activation of BK channel and leading to low [K+]i in the hippocampal neurons. BK channel inhibitor IbTx inhibits activation of NLRP1 inflammasome by blocking BK channel and increases [K+]i, which decreased by DEX treatment