Skip to main content

Table 1 Subarachnoid hemorrhage (SAH)-induced cerebral blood flow changes in rats

From: Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats

Subgroup

Number of animals

CBF changes (% of the initial values)

1 min post-SAH

20 min post-SAH

Sham surgery (group 1)

16

90.3 ± 7.7

103.2 ± 6.1

SAH surgery (group 2)

10

14.6 ± 3.5*

64.2 ± 5.9*

SAH surgery + vehicle (group 3)

6

16.9 ± 5.2*

62.3 ± 9.0*

SAH surgery + heparanase

inhibitor (group 4)

6

15.3 ± 5.7*

58.2 ± 4.6*

  1. Cerebral blood flow (CBF) changes were measured throughout SAH surgical procedure. CBF changes were calculated for 30 min post-SAH and expressed as percentage of initial CBF values. SAH was accompanied with an abrupt CBF drop, followed by a gradual recovery toward its initial value and reached a plateau after 20 min. Three hours post-SAH, animals in groups 3 and 4 received intracerebroventricular treatment of either vehicle (aCSF) or heparanase inhibitor (OGT2115) via Alzet osmotic pump installation. Values are mean ± SE
  2. *p < 0.05 vs the sham surgical controls