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Table 1 Subarachnoid hemorrhage (SAH)-induced cerebral blood flow changes in rats

From: Heparanase promotes neuroinflammatory response during subarachnoid hemorrhage in rats

Subgroup Number of animals CBF changes (% of the initial values)
1 min post-SAH 20 min post-SAH
Sham surgery (group 1) 16 90.3 ± 7.7 103.2 ± 6.1
SAH surgery (group 2) 10 14.6 ± 3.5* 64.2 ± 5.9*
SAH surgery + vehicle (group 3) 6 16.9 ± 5.2* 62.3 ± 9.0*
SAH surgery + heparanase
inhibitor (group 4)
6 15.3 ± 5.7* 58.2 ± 4.6*
  1. Cerebral blood flow (CBF) changes were measured throughout SAH surgical procedure. CBF changes were calculated for 30 min post-SAH and expressed as percentage of initial CBF values. SAH was accompanied with an abrupt CBF drop, followed by a gradual recovery toward its initial value and reached a plateau after 20 min. Three hours post-SAH, animals in groups 3 and 4 received intracerebroventricular treatment of either vehicle (aCSF) or heparanase inhibitor (OGT2115) via Alzet osmotic pump installation. Values are mean ± SE
  2. *p < 0.05 vs the sham surgical controls