Fig. 2

Surgery impaired hippocampal-dependent memory, but not hippocampal-independent memory. JWH133 treatment alleviated postoperative hippocampal-dependent memory loss, while AM630 treatment aggravated it. The percent freezing time in the context test (a–c) and tone test (d–f) were assessed 1, 3, and 7 days after surgery. The data are plotted as the mean ± standard error of the mean for each group (n = 6 per group). *p < 0.05 versus the control group, ^# p < 0.05 versus the surgery group