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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Activation of cannabinoid receptor type 2 attenuates surgery-induced cognitive impairment in mice through anti-inflammatory activity

Fig. 4

Surgery resulted in an increased expression of proinflammatory factors in the prefrontal cortex. JWH133 treatment alleviated the surgery-induced upregulation of proinflammatory factors in the prefrontal cortex, while AM630 aggravated it. Representative Western blotting bands show the expression of IL-1β, TNF-α, and MCP-1 in the prefrontal cortex 1, 3, and 7 days after surgery (ac). Expression levels of IL-1β, TNF-α, and MCP-1 were normalized to that of GAPDH as an internal control (dl). The data are plotted as the mean ± standard error of the mean for each group (n = 3 per group). *p < 0.05 versus the control group, # p < 0.05 versus the surgery group

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