Fig. 4
PAR2-AP potentiation of proton-gated currents mediated by heteromeric ASIC3 channels. Representative a current traces and b bar graphs show that I pH 6.6 was also enhanced by PAR2-AP (10−5 M) pre-applied for 1 min in CHO cells co-expressing PAR2 and heteromeric ASIC3 plus 1a, 1b, 2a, or 2b channels. n = 8 in each column. The c current traces and d bar graphs show that PAR2-AP and trypsin had no effect on I pH 6.6 in CHO cells expressing alone homomeric ASIC3, but not expressing PAR2. Currents were normalized to control (100%, white column). n = 10 in each column