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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury

Fig. 1

Effects of ω-3 PUFA supplementation on neurological function, brain edema, and neuronal apoptosis after TBI. a ω-3 PUFA supplementation improved neurological functions 7 days after TBI (8.14 ± 0.31 vs. 9.93 ± 0.42, p < 0.05). b ω-3 PUFA supplementation decreased brain water content 3 days after TBI (80.37 ± 0.54% vs. 83.62 ± 0.73%, p < 0.05). c A schematic of a brain section after TBI. Areas in red refer to the lesion sites, and areas in blue refer to the sample points, d, e ω-3 PUFA supplementation decreased neuronal apoptosis in lesioned cortices (53.47 ± 6.54% vs. 84.50 ± 8.69%, p < 0.05). Representative photomicrographs of Nissl staining in the experimental groups. Arrows point to apoptotic neurons; n = 6 in each group. The values are expressed as mean ± standard deviation: *p < 0.05, **p < 0.01, scale bars = 50 μm

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