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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury

Fig. 3

ω-3 PUFA supplementation inhibits HMGB1 expression in lesioned cortices. a HMGB1 immunoreactivity in the cortex was significantly decreased by ω-3 PUFA supplementation (1.92 ± 0.22 vs. 2.86 ± 0.39, p < 0.05). b ω-3 PUFA supplementation significantly decreased HMGB1 expression in cytosolic and total cellular protein levels (p < 0.05), but not nuclear protein (p > 0.05). c SIRT1 protein level was upregulated after ω-3 PUFA supplementation; n = 6 in each group. The values are expressed as mean ± standard deviation: *p < 0.05, **p < 0.01, scale bars = 50 μm

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