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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Omega-3 polyunsaturated fatty acid supplementation attenuates microglial-induced inflammation by inhibiting the HMGB1/TLR4/NF-κB pathway following experimental traumatic brain injury

Fig. 4

ω-3 PUFA supplementation inhibits HMGB1 expression in lesioned cortices. a TBI enhanced the expression of HMGB1 in neurons (NeuN+), which was significantly decreased by ω-3 PUFA supplementation (p < 0.05). Arrows point to HMGB1-positive neurons. b TBI enhanced the expression of HMGB1 in microglial cells (Iba-1+), which was significantly decreased by ω-3 PUFA supplementation (p < 0.05). Arrows point to HMGB1-positive microglial cells (Iba-1+). c ω-3 PUFA supplementation decreased the expression of cleaved caspase-3 and Bax in lesioned cortices (p < 0.05); n = 6 in each group. The values are expressed as mean ± standard deviation: *p < 0.05, **p < 0.01, scale bars = 50 μm

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