Fig. 1

Role of TLR4 in the expression of cytokines (IL-1β, IL-17) and chemokines (fractalkine, MCP-1, MIP-1α) in (a) maternal serum and amniotic fluid on E15, (b) in the maternal cerebral cortices of the WT and TLR4-KO pregnant female dams which underwent, or did not, chronic ethanol consumption, and (c) in the cerebral cortices of the WT and TLR4-KO embryos and pups on E15 and PND 0, 20, and 66 exposed, or not, to ethanol during the embryonic and postnatal periods. PPEE prenatal and postnatal ethanol exposure. Data represent mean ± SEM, n = 8 mice/group. *p < 0.05, **p < 0.01, ***p < 0.001, compared to their respective control group, $p < 0.05, $$p < 0.01 compared to their corresponding control WT group