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Table 3 Role of TLR4 in the EPM in WT and TLR4-KO mice at PND 66 exposed or not to ethanol during the gestational and postnatal period

From: TLR4 response mediates ethanol-induced neurodevelopment alterations in a model of fetal alcohol spectrum disorders

  WT WT PPEE TLR4-KO TLR4-KO PPEE
Time in OA (s) 98 ± 9 24 ± 6** 101 ± 13 101 ± 30++
% time in OA 43 ± 4 10 ± 3*** 44 ± 14 40 ± 10+++
Time in center (s) 72 ± 7 57 ± 9 69 ± 8 61 ± 16
Time in CA (s) 130 ± 1 220 ± 13*** 126 ± 14 138 ± 26++
OA entries 10 ± 2 2 ± 1 8 ± 1 2 ± 1
% OA entries 46 ± 3 21 ± 3 56 ± 3 50 ± 9
Closed entries 12 ± 1 8 ± 1 6 ± 1 4 ± 1
Total entries 22 ± 2 10 ± 1 14 ± 1 6 ± 1
  1. OA open arms and CA closed arms. Data are presented as mean (± SEM), n = 11–15 mice/group. **p < 0.01, ***p < 0.001, as compared to the control WT mice; ++p < 0.01, +++p < 0.001, as compared to the ethanol WT mice. PPEE prenatal and postnatal ethanol exposure