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Table 3 Role of TLR4 in the EPM in WT and TLR4-KO mice at PND 66 exposed or not to ethanol during the gestational and postnatal period

From: TLR4 response mediates ethanol-induced neurodevelopment alterations in a model of fetal alcohol spectrum disorders

 

WT

WT

PPEE

TLR4-KO

TLR4-KO

PPEE

Time in OA (s)

98 ± 9

24 ± 6**

101 ± 13

101 ± 30++

% time in OA

43 ± 4

10 ± 3***

44 ± 14

40 ± 10+++

Time in center (s)

72 ± 7

57 ± 9

69 ± 8

61 ± 16

Time in CA (s)

130 ± 1

220 ± 13***

126 ± 14

138 ± 26++

OA entries

10 ± 2

2 ± 1

8 ± 1

2 ± 1

% OA entries

46 ± 3

21 ± 3

56 ± 3

50 ± 9

Closed entries

12 ± 1

8 ± 1

6 ± 1

4 ± 1

Total entries

22 ± 2

10 ± 1

14 ± 1

6 ± 1

  1. OA open arms and CA closed arms. Data are presented as mean (± SEM), n = 11–15 mice/group. **p < 0.01, ***p < 0.001, as compared to the control WT mice; ++p < 0.01, +++p < 0.001, as compared to the ethanol WT mice. PPEE prenatal and postnatal ethanol exposure
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Journal of Neuroinflammation

ISSN: 1742-2094