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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging

Fig. 3

Pathway, function, and regulatory analysis of age-related transcriptomic changes. Age-related gene expression changes were analyzed with Ingenuity Knowledge Base for differentially regulated pathways (a), functions (b), and regulators (c). A relevant selection of over-represented categories (Fisher’s exact test p < 0.05) is given in heatmap form with coloring according to the computed z score. Z scores are based on prior knowledge of known regulatory functions and direction of changes in the current dataset. Z scores >2 indicate significant activation with aging and <−2 indicate significant inhibition with aging. Abbreviations are detailed in Additional file 1: Table S8

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