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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging

Fig. 6

Pathway, function, and regulatory analysis of sex differences in gene expression. A selection of statistically over-represented pathways (a), functions (b), and regulators (c) are presented with z scores is given in heatmap form with coloring according to the computed z score. Z scores are based on prior knowledge of known regulatory functions and direction of changes in the current dataset. Z scores >2 indicate significant activation in females as compared to males and <−2 indicate significant inhibition in females compared to males. d Cell-specific transcripts from previous reports [30, 31]) were compared to each pairwise set of sex differences. Fisher’s exact test p values are plotted for cell types with significant over-representations. Gen sets derived for the sensome, classical priming, and alternative microglial priming [32] (e),and gene sets indicative of M0, M1, and M2 microglial states (f) [33] were also examined for over-representation of age-related genes. Abbreviations are detailed in Additional File: Table S10

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