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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Effects of FTY720 on brain neurogenic niches in vitro and after kainic acid-induced injury

Fig. 2

KA icv injection increases cell proliferation in dentate gyrus (DG). a Scheme of in vivo experimental protocol and b schematic diagram of the DG. Positive cells were considered to be within the SGZ if they were within two cell body diameters of the border between the GCL and the hilus. c Quantitative analysis of the immunoperoxidase staining for BrdU in ipsilateral (ipsi) and contralateral (contra) SGZ of the dorsal hippocampus in control, FTY720, KA and KA + FTY720-treated animals. Immunoreactive cells for BrdU were counted in two sections per rat using a bright field microscopy and a 40× objective. Data were plotted as the mean of BrdU+ cells per slice ± SEM. Statistical analysis: one-way ANOVA followed by Bonferroni post hoc test; **p < 0.01 vs control. Two-way ANOVA showed no significant difference between ipsilateral and contralateral BrdU+ cells in SGZ. N = 6 for each experimental group. d Representative images of immunoperoxidase staining of BrdU in ipsilateral and contralateral DG in all experimental groups. Scale bar: 200 μm

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