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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Protective and therapeutic role of 2-carba-cyclic phosphatidic acid in demyelinating disease

Fig. 5

Effects of 2ccPA in the multiperiod of CPZ-induced demyelination and motor dysfunction. Black-Gold II staining of control (a, e, and i), CPZ + saline (b, f, and j), CPZ + 2ccPA (c, g, and k). Myelin densities in the corpus callosum (d, h, and l) were compared with controls and expressed as a percentage of control value using the ImageJ analysis program. Data are mean ± SEM., n = 5 animals. Statistical analysis was performed using one-way ANOVA followed by post hoc Newman-Keuls test (***p < 0.001 vs. control; ## p < 0.01; ### p < 0.001 vs. CPZ + saline). Scale bars = 500 μm. Motor performance on the rotarod. Mice were assessed for locomotion time during a period of 300 s (m, o, and q). Data are mean ± SEM., n = 12 animals. Statistical analysis was performed using one-way ANOVA followed by post hoc Newman-Keuls test (***p < 0.001 vs. control; ### p < 0.001 vs. CPZ + saline). Number of falls and flips (n, p, and r). Data are mean ± SEM., n = 12 animals (0–5 weeks group), n = 10 animals (3–5 weeks group), and n = 15 animals (5–10 weeks group). Statistical analysis was performed using non-parametric Kruskal-Wallis test (*p < 0.05; ***p < 0.001 vs. control; # p < 0.05; ### p < 0.001 vs. CPZ + saline)

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