Fig. 1

Disease course in mice treated with FTY720 either in the acute or chronic stage of EAE. MP4-immunized mice were treated with 1 mg/kg BW FTY720 or vehicle a at the peak of the disease or b 50 days after EAE onset. c, d Representative disease course of individual animals treated during c acute or d chronic EAE. Arrows indicate treatment onset. e, f Flow cytometry of CD4⁺ T cells and CD19⁺ B cells in the blood after treatment with FTY720 compared to vehicle. Mice were treated 50 days after disease onset. *p < 0.05, **p < 0.01, ***p < 0.001, Mann-Whitney test. Bars in a and b show mean values ± SEM