Skip to main content
Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: microRNA dysregulation in polyglutamine toxicity of TATA-box binding protein is mediated through STAT1 in mouse neuronal cells

Fig. 6

Spent media from 59Q-TBP cells carry factor(s) that modulate the levels of miR-29a/b. Neuro-2a cells were transfected with 16Q-TBP (16Q) or 59Q-TBP (59Q) and the supernatant media collected after 36 h (a). Neuro-2a cells were treated with this spent media (− in b, middle panel, c-d) or incubated with neutralizing antibody against IFN-γ before treatment on cells (+ in b, right panel, c-d). STAT1 (b) and miR-29a/b (c-d) levels were monitored using qRT-PCR and normalized to Gapdh (b) and miR-92a (c-d). (n = 3; * p value ≤0.01; ** p value ≤0.001)

Back to article page