Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation

Table 1 Global transcriptome analysis with prominent pathway dysregulations upon STRING assessment at 3 ages in different brain regions of Pink1 ^−/− mice, illustrated as heat maps

Expression dysregulations in Affymetrix microarrays are shown in different brain regions (C = cerebellum, M = midbrain, S = striatum) across the mouse lifespan (6 W = 6 weeks, 24 W = 24 weeks = 6 months, 18 M = 18 months), for genes detected by a specific oligonucleotide probe ID, together with the Adjusted p values (AdjPval) as determined by Affymetrix transcriptome bioinformatics via software platform R and the bioconductor package Limma. Displayed are the genes contained in five exemplary pathways, which exhibited significant enrichment according to STRING bioinformatics, as indicated by the false discovery rate q values. The ranked order of all dysregulated pathways upon STRING assessment can be found in Additional file 3: Table S2

ISSN: 1742-2094