Skip to main content

Advertisement

Table 2 Frequency of intrathecal total IgG synthesis; oligoclonal IgG pattern; IgG CSF/serum ratios; intrathecal IgG fractions; absolute amount of locally produced IgG; and CSF and serum IgG concentrations

From: Pattern II and pattern III MS are entities distinct from pattern I MS: evidence from cerebrospinal fluid analysis

  Units Pattern I MS Pattern II + III MS Pattern II MS Pattern III MS AQP4-IgG+ NMO [48] MOG-IgG+ EM [35]
CSF-restricted OCB Samples 15/17 (88.2) 10/37 (27) 9/25 (36) 1/12 (8.3) 29/177 (16.4) 8/47 (17)
CSF-restricted OCB Patients 8/10 (80) 7/22 (31.8) 6/16 (37.5) 1/6 (16.7) 22/80 (27.5) 6/45 (13)
CSF-restricted OCB, without transient OCB Patients 8/10 (80) 5/22 (22.7) 5/16 (31.3) 0/6 (0) 16/80 (20) 6/45 (13)
OCB, IEF pattern 1 Samples 2/15 (13.3) 24/35 (68.6) 13/23 (56.5) 11/12 (91.7) 127/177 (71.8) n.d.
OCB, IEF pattern 2 Samples 13/15 (86.7) 7/35 (20) 6/23 (26.1) 1/12 (8.3) 19/177 (10.7) n.d.
OCB, IEF pattern 3 Samples 0/15 (0) 1/35 (2.9) 1/23 (4.3) 0/12 (0) 10/177 (5.6) n.d.
OCB, IEF pattern 4 Samples 0/15 (0) 1/35 (2.9) 1/23 (4.3) 0/12 (0) 20/177 (11.3) n.d.
OCB, IEF pattern 5 Samples 0/15 (0) 3/35 (8.6) 2/23 (8.7) 1/12 (8.3) 1/177 (0.6) n.d.
QIgG > Qlim(IgG) Patients 3/10 (30) 4/21 (19) 4/14 (28.6) 0/7 (0) n.d. n.d.
QIgG > Qlim(IgG) Samples 7/17 (41.2) 5/41 (12.2) 5/24 (20.8) 0/17 (0) 13/143 (9) n.d.
QIgG, all LPs 3.6 (1.9–9.35; 17) 4.75 (1.3–21.5; 42) 4.8 (1.3–21.5; 25) 4.7 (1.98–12.6; 17) 3.9 (0.2–58.1; 135) n.d.
QIgG, if positive 3.63 (2.6–9.35; 7) 5.03 (3.2–8.8; 5) 5.03 (3.2–8.8; 5) n.a. 5.7 (2.5–58.1; 12) n.d.
IgGloc, all LPs mg/L 0 (0–75.76; 17) 0 (0–51.17; 41) 0 (0–51.17; 24) 0 (0–0; 17) 0 (0–441.4; 135) n.d.
IgGloc, QIgG positives mg/L 5.91 (2.31–75.76; 7) 16.75 (11.79–51.17; 5) 16.75 (11.79–51.17; 5) n.a. 13.9 (1.3–441.4; 12) n.d.
IgGIF, all LPs % 0 (0–0.58; 17) 0 (0–0.59; 41) 0 (0–0.59; 24) 0 (0–0; 17) 0 (0–90.6; 135) n.d.
IgGIF, QIgG positives % 0.14 (0.06–0.58; 7) 0.47 (0.22–0.59; 5) 0.47 (0.22–0.59; 5) n.a. 32.5 (2.8–90.6; 12) n.d.
IgG CSF, all LPs mg/L 39.9 (11–130; 17) 43.7 (11.4–146; 41) 46 (11.4–109; 24) 37.7 (21–146; 17) 37.9 (2.4–487; 136) n.d.
IgG CSF, QIgG positives mg/L 39.9 (16.8–130; 7) 53.3 (22.9–109; 5) 53.3 (22.9–109; 5) n.a. 70.6 (20.5–487; 12) n.d.
IgG serum, all LPs g/L 10 (3.9–28.04; 17) 8.75 (5.55–28.9; 41) 10.39 (5.55–24.8; 24) 7.5 (6.15–28.9; 17) 10 (1.9–55.8; 134) n.d.
IgG serum, QIgG positives g/L 9.21 (3.9–15.3; 7) 8.75 (7.1–12.4; 5) 8.75 (7.1–12.4; 5) n.a. 10.7 (2.4–18; 12) n.d.
  1. n.a. not applicable, n.d. no data
  2. Concentrations, ratios and fractions are reported as medians; range and total sample numbers examined are given in brackets