Table 3 Frequency of intrathecal IgM and IgA synthesis; IgM and IgA CSF/serum ratios; intrathecal IgM and IgA fractions; amount of locally produced IgM and IgA; and absolute CSF and serum IgM and IgA concentrations

QIgM > Q_lim(IgM)

Patients

3/9 (33.3)

3/17 (17.6)

3/12 (25)

0/5 (0)

n.d.

QIgM > Q_lim(IgM), LPs

Samples

3/16 (18.8)

5/30 (16.7)

5/20 (25)

0/10 (0)

13/96 (14%)

QIgM, all LPs

–

0.58 (0.26–1.5; 15)

0.65 (0.1–14.1; 26)

0.8 (0.1–14.1; 17)

0.6 (0.5–5.8; 9)

0.9 (0–40.5; 97)

QIgM, if positive

–

0.8 (0.58–1.5; 3)

9.8 (3.5–14.1; 5)

9.8 (3.5–14.1; 5)

n.a.

8.3 (1.2–40.5; 13)

IgM_loc, all LPs

mg/L

0 (0–0.27; 16)

0 (0–9.24; 29)

0 (0–9.24; 19)

0 (0–0; 10)

0 (0–35.3; 95)

IgM_loc, QIgM positives

mg/L

0.12 (0.05–0.27; 3)

6.41 (0.86–9.24; 5)

6.41 (0.86–9.24; 5)

n.a.

0.9 (0–35.3; 13)

IgM_IF, all LPs

%

0 (0–0.12; 16)

0 (0–0.86; 30)

0 (0–0.86; 20)

0 (0–0; 10)

0 (0-95.8; 95)

IgM_IF, QIgM positives

%

0.1 (0.09-0.12; 3)

0.71 (0.17–0.86; 5)

0.71 (0.17–0.86; 5)

n.a.

15.3 (2.3–95.8; 13)

IgM CSF, all LPs

mg/L

1 (0.4–3; 15)

1.05 (0.2–17.8; 26)

1.2 (0.2–17.8; 17)

0.9 (0.54–11; 9)

0.7 (0–36.9; 100)

IgM CSF, QIgM positives

mg/L

1.2 (0.42–3; 3)

9 (5.4–17.8; 5)

9 (5.4–17.8; 5)

n.a.

n.d.

IgM serum, all LPs

g/L

1.68 (0.56–3.75; 16)

1.6 (0.38–3.68; 29)

1.45 (0.38–3.68; 20)

1.7 (0.9–2.2; 9)

0.96 (0.13–2.85; 99)

IgM serum, QIgM positives

g/L

1.51 (0.72–2; 3)

1.1 (0.64–1.5; 5)

1.1 (0.64–1.5; 5)

n.a.

n.d.

QIgA > Q_lim(IgA)

Patients

2/8 (25)

1/17 (5.9)

1/12 (8.3)

0/5 (0)

n.d.

QIgA > Q_lim(IgA)

Samples

2/15 (13.3)

1/29 (3.4)

1/19 (5.3)

0/10 (0)

5/88 (6%)

QIgA, all LPs

–

1.77 (1.01–5.7; 13)

2.5 (0.82–9.1; 29)

2.4 (1–6.6; 19)

3.3 (0.82–9.1; 10)

2.1 (0–40.4; 88)

QIgA, if positive

–

3.22 (1.73–4.7; 2)

1 (1–1; 1)

1 (1–1; 1)

n.a.

5.1 (3.7–20.2; 5)

IgA_loc, all LPs

mg/L

0 (0–3.72; 15)

0 (0–0.08; 29)

0 (0–0.08; 19)

0 (0–0; 10)

0 (0–3.2; 86)

IgA_loc, QIgA positives

mg/L

2.015 (0.31–3.72; 2)

0.08 (0.08–0.08; 1)

0.08 (0.08–0.08; 1)

n.a.

0.3 (0.03–3.2; 5)

IgA_IF, all LPs

%

0 (0–0.73; 15)

0 (0–0.08; 29)

0 (0–0.08; 19)

0 (0–0; 10)

0 (0–7.5; 86)

IgA_IF, QIgA positives

%

0.425 (0.12–0.73; 2)

0.08 (0.08–0.08; 1)

0.08 (0.08–0.08; 1)

n.a.

5.6 (0.5–7.5; 5)

IgA CSF, all LPs

mg/L

2.7 (1.4–16.6; 13)

4.55 (0.24–19.9; 30)

3.45 (0.24–17.5; 20)

8.5 (3.1–19.9; 10)

4.7 (0–131; 95)

IgA CSF, QIgA positives

mg/L

3.79 (2.5–5.08; 2)

1.1 (1.1–1.1; 1)

1.1 (1.1–1.1; 1)

n.a.

n.d.

IgA serum, all LPs

g/L

1.53 (0.9–2.9; 15)

1.88 (0.53–3.8; 29)

1.55 (0.53–3; 19)

2.6 (1.2–3.8; 10)

0.96 (0.13–2.85; 99)

IgA serum, QIgA positives

g/L

1.26 (1.08–1.45; 2)

1.1 (1.1–1.1; 1)

1.1 (1.1–1.1; 1)

n.a.

n.d.