Skip to main content

Advertisement

Table 5 Frequency of intrathecal IgG synthesis to infectious agents

From: Pattern II and pattern III MS are entities distinct from pattern I MS: evidence from cerebrospinal fluid analysis

  Units MS, according to literature [14] Pattern I MS Pattern II + III MS Pattern II MS Pattern III MS AQP4-IgG+ NMO [13, 23, 43, 55, 56] MOG-IgG+ EM [35]
MRZ reaction (≥2 AIs >1.5) Patients 72/100 (72) 1/2 (50) 0/10 (0) 0/7 (0) 0/3 (0) 1/42 (2.4) 0/11 (0)
  Samples 72/100 (72) 1/2 (50) 0/12 (0) 0/8 (0) 0/4 (0) 1/42 (2.4) 0/11 (0)
M and/or R and/or Z >1.5 Samples 158/177 (89) 1/2 (50) 1/11 (9.1) 0/8 (0) 1/3 (33.3) n.d. n.d.
 Measles virus AI >1.5 Samples 138/177 (78) 1/2 (50) 1/10 (10) 0/8 (0) 1/4 (25) 1/42 (2.4) 0/11 (0)
 Rubella virus AI >1.5 Samples 106/177 (60) 1/2 (50) 0/9 (0) 0/8 (0) 0/4 (0) 0/42 (0) 0/11 (0)
 Zoster virus AI >1.5 Samples 97/177 (55) 0/2 (0) 0/9 (0) 0/8 (0) 0/4 (0) 1/42 (2.4) 0/11 (0)
Herpes simplex virus AI >1.5 Samples 26/94 (28) n.d. 0/4 (0) 0/4 (0) 0/1 (0) n.d. n.d.
Epstein–Barr virus AI >1.5 Samples n.d. 0/2 (0) 0/2 (0) n.d. n.d. n.d. 0/2 (0)
Borrelia burgdorferi AI >1.5 Samples 0/1 (0) 0/3 (0) 0/6 (0) 0/2 (0) n.d. 0/1 (0) 0/3 (0)
Toxoplasma gondii AI >1.5 Samples n.d. 0/1 (0) 0/1 (0) n.d. n.d. n.d. 0/1 (0)
TPHA AI >1.5 Samples n.d. 0/1 (0) 0/1 (0) n.d. n.d. n.d. 0/1 (0)
  1. n.a. not applicable AI antibody index, M measles virus, R rubella virus, TPHA Treponema pallidum haemagglutination assay, Z varicella zoster virus