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Table 5 Frequency of intrathecal IgG synthesis to infectious agents

From: Pattern II and pattern III MS are entities distinct from pattern I MS: evidence from cerebrospinal fluid analysis

 

Units

MS, according to literature [14]

Pattern I MS

Pattern II + III MS

Pattern II MS

Pattern III MS

AQP4-IgG+ NMO [13, 23, 43, 55, 56]

MOG-IgG+ EM [35]

MRZ reaction (≥2 AIs >1.5)

Patients

72/100 (72)

1/2 (50)

0/10 (0)

0/7 (0)

0/3 (0)

1/42 (2.4)

0/11 (0)

 

Samples

72/100 (72)

1/2 (50)

0/12 (0)

0/8 (0)

0/4 (0)

1/42 (2.4)

0/11 (0)

M and/or R and/or Z >1.5

Samples

158/177 (89)

1/2 (50)

1/11 (9.1)

0/8 (0)

1/3 (33.3)

n.d.

n.d.

 Measles virus AI >1.5

Samples

138/177 (78)

1/2 (50)

1/10 (10)

0/8 (0)

1/4 (25)

1/42 (2.4)

0/11 (0)

 Rubella virus AI >1.5

Samples

106/177 (60)

1/2 (50)

0/9 (0)

0/8 (0)

0/4 (0)

0/42 (0)

0/11 (0)

 Zoster virus AI >1.5

Samples

97/177 (55)

0/2 (0)

0/9 (0)

0/8 (0)

0/4 (0)

1/42 (2.4)

0/11 (0)

Herpes simplex virus AI >1.5

Samples

26/94 (28)

n.d.

0/4 (0)

0/4 (0)

0/1 (0)

n.d.

n.d.

Epstein–Barr virus AI >1.5

Samples

n.d.

0/2 (0)

0/2 (0)

n.d.

n.d.

n.d.

0/2 (0)

Borrelia burgdorferi AI >1.5

Samples

0/1 (0)

0/3 (0)

0/6 (0)

0/2 (0)

n.d.

0/1 (0)

0/3 (0)

Toxoplasma gondii AI >1.5

Samples

n.d.

0/1 (0)

0/1 (0)

n.d.

n.d.

n.d.

0/1 (0)

TPHA AI >1.5

Samples

n.d.

0/1 (0)

0/1 (0)

n.d.

n.d.

n.d.

0/1 (0)

  1. n.a. not applicable AI antibody index, M measles virus, R rubella virus, TPHA Treponema pallidum haemagglutination assay, Z varicella zoster virus