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Table 6 Blood–CSF barrier function and albumin levels

From: Pattern II and pattern III MS are entities distinct from pattern I MS: evidence from cerebrospinal fluid analysis

  Units Pattern I MS Pattern II + III MS Pattern II MS Pattern III MS AQP4-IgG+ NMO [48]
QAlb > Qlim(Alb) Patients 4/10 (40) 15/22 (68.2) 9/15 (60) 6/7 (85.7) n.d.
QAlb > Qlim(Alb) Samples 4/17 (23.5) 30/43 (69.8) 16/26 (61.5) 14/17 (82.4) 75/147 (51%)
QAlb, all LPs 4.81 (3.01–10.8; 17) 8.39 (2.1–33.9; 42) 7.3 (2.1–33.9; 25) 9 (3.3–20.7; 17) 7 (2.3–57.1; 137)
QAlb, QAlb pos. 8.53 (6.3–10.8; 4) 9.8 (6.4–33.9; 29) 9 (6.4–33.9; 15) 10.25 (6.8––20.7; 14) 11.8 (5.63–57.14; 70)
Albumin CSF, all LPs mg/L 204 (95–517; 17) 331 (81.2–726; 41) 255.5 (81.2–599; 24) 368 (137–726; 17) 284 (83.6–1890; 139)
Albumin CSF, QAlb pos. mg/L 366 (251–517; 4) 371.5 (227–726; 28) 312 (227–599; 14) 431 (282–726; 14) 437 (219–1890)
Albumin serum, all LPs g/L 40.6 (29.3–49.5; 17) 40 (22.6–51.8; 41) 39.85 (22.6–51.4; 24) 41.2 (32.7–51.8; 17) 40.7 (19.7–67.9; 133)
Albumin serum, QAlb pos. g/L 43.15 (37.7–47.9; 4) 39.5 (22.6–50.9; 27) 35.55 (22.6–46.8; 14) 39.9 (32.7–50.9; 13) 39 (19.7–55.9)
Combined intrathecal IgG synthesis and disturbed blood–CSF barrier function
 Patients, at least once N (%) 3/10 (30) 4/20 (20) 3/13 (23.1) 1/7 (14.3) n.d.
 All LPs N (%) 3/17 (17.6) 5/43 (11.6) 4/26 (15.4) 1/17 (5.9) 13/74 (17.6%)
  1. n.d. no data
  2. QAlb = CSF/serum albumin ratio. Concentrations and ratios are reported as medians; range and total sample numbers examined are given in brackets