Skip to main content

Table 6 Blood–CSF barrier function and albumin levels

From: Pattern II and pattern III MS are entities distinct from pattern I MS: evidence from cerebrospinal fluid analysis

 

Units

Pattern I MS

Pattern II + III MS

Pattern II MS

Pattern III MS

AQP4-IgG+ NMO [48]

QAlb > Qlim(Alb)

Patients

4/10 (40)

15/22 (68.2)

9/15 (60)

6/7 (85.7)

n.d.

QAlb > Qlim(Alb)

Samples

4/17 (23.5)

30/43 (69.8)

16/26 (61.5)

14/17 (82.4)

75/147 (51%)

QAlb, all LPs

4.81 (3.01–10.8; 17)

8.39 (2.1–33.9; 42)

7.3 (2.1–33.9; 25)

9 (3.3–20.7; 17)

7 (2.3–57.1; 137)

QAlb, QAlb pos.

8.53 (6.3–10.8; 4)

9.8 (6.4–33.9; 29)

9 (6.4–33.9; 15)

10.25 (6.8––20.7; 14)

11.8 (5.63–57.14; 70)

Albumin CSF, all LPs

mg/L

204 (95–517; 17)

331 (81.2–726; 41)

255.5 (81.2–599; 24)

368 (137–726; 17)

284 (83.6–1890; 139)

Albumin CSF, QAlb pos.

mg/L

366 (251–517; 4)

371.5 (227–726; 28)

312 (227–599; 14)

431 (282–726; 14)

437 (219–1890)

Albumin serum, all LPs

g/L

40.6 (29.3–49.5; 17)

40 (22.6–51.8; 41)

39.85 (22.6–51.4; 24)

41.2 (32.7–51.8; 17)

40.7 (19.7–67.9; 133)

Albumin serum, QAlb pos.

g/L

43.15 (37.7–47.9; 4)

39.5 (22.6–50.9; 27)

35.55 (22.6–46.8; 14)

39.9 (32.7–50.9; 13)

39 (19.7–55.9)

Combined intrathecal IgG synthesis and disturbed blood–CSF barrier function

 Patients, at least once

N (%)

3/10 (30)

4/20 (20)

3/13 (23.1)

1/7 (14.3)

n.d.

 All LPs

N (%)

3/17 (17.6)

5/43 (11.6)

4/26 (15.4)

1/17 (5.9)

13/74 (17.6%)

  1. n.d. no data
  2. QAlb = CSF/serum albumin ratio. Concentrations and ratios are reported as medians; range and total sample numbers examined are given in brackets