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Table 9 Summary of differences in CSF parameters between various MS subgroups as observed in the present study

From: Pattern II and pattern III MS are entities distinct from pattern I MS: evidence from cerebrospinal fluid analysis

Parameter Diagnostic groups Results P values
CSF-restricted OCB, all LPs Pattern I 15/17 (88.2) P < 0.00004
Patterns II + III 10/37 (27)  
Reiber et al. [19] 262/267 (98) P < 0.000001
Patterns II + III 10/37 (27)  
Pattern I 15/17 (88.2) P < 0.0001
Pattern II 9/25 (36)  
Pattern III 1/12 (8.3)  
CSF-restricted OCB, patients Pattern I 8/10 (80) P < 0.03
Patterns II + III 7/22 (31.8)  
Reiber et al. [19] 262/267 (98) P < 0.000001
Patterns II + III 7/22 (31.8)  
CSF-restricted OCB, patients, w/o transient OCBs Pattern I 8/10 (80) P < 0.006
Patterns II + III 5/22 (22.7)  
Reiber et al. [19] 262/267 (98) P < 0.00001
Patterns II + III 5/22 (22.7)  
MRZ reaction (≥2 AIs >1.5), all LPs Jarius et al. [23] 397/546 (69) P < 0.000001
Patterns II + III 0/12 (0)  
M and/or R and/or Z >1.5, all LPs Reiber et al. [19] 158/177 (89) P < 0.000001
Patterns II + III 0/12 (0)  
QIgG > Qlim(lgG), all LPs Pattern I 7/17 (41.2) P < 0.03
Patterns II + III 5/41 (12.2)  
QAlb > Qlim(Alb), all LPs Pattern I 4/17 (23.5) P < 0.002
Patterns II + III 30/43 (69.8)  
Pattern I 4/17 (23.5) P = 0.002
Pattern II 16/26 (61.5)  
Pattern III 14/17 (82.4)  
QAlb, all LPs Pattern I 4.81 (3.01–10.8; 17) P < 0.005
Patterns II + III 8.39 (2.1–33.9; 42)  
Albumin CSF, all LPs Pattern I 204 (95–517; 17) P < 0.009
Patterns II + III 331 (81.2–726; 41)  
Total CSF protein elevated, all LPs Pattern I 3/15 (20) P < 0.003
Patterns II + III 29/43 (67.4)  
Total CSF protein, all LPs Pattern I 375 (187–750; 15) P < 0.007
Patterns II + III 550 (168–1930; 43)  
Albuminocytological dissociation, all LPs Pattern I 1/8 (12.5) P < 0.04
Patterns II + III 13/21 (61.9)  
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