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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Brain-derived neurotrophic factor reduces inflammation and hippocampal apoptosis in experimental Streptococcus pneumoniae meningitis

Fig. 6

BDNF inhibited MyD88 expression in PM. MyD88 mRNA levels in the a hippocampus and b cortex increased at 24 h post-infection. BDNF pretreatment inhibited the upregulation of MyD88 mRNA, whereas rats pretreated with k252a showed increased MyD88 expression as compared with that observed in the BDNF + PM group. Western blot analysis confirmed lower levels of MyD88 protein in the c, e hippocampus and d, f cortex following BDNF treatment, whereas these results were not observed in the k252a + PM group. **p < 0.01

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Journal of Neuroinflammation

ISSN: 1742-2094