Fig. 7

BDNF reduces NF-κB-binding activity in the cortex at 24 h post-infection. a NF-κB DNA-binding activity examined by EMSA revealed increased NF-κB-binding activity in all infected mice relative to levels observed in the sham group. BDNF pretreatment inhibited NF-κB-binding activity as compared with levels observed in the PBS + PM group, and pretreatment with k252a significantly increased NF-κB-binding activity as compared with activity observed in the BDNF + PM group. b Quantitative analysis of the EMSA results. **p < 0.01