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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: Age exacerbates microglial activation, oxidative stress, inflammatory and NOX2 gene expression, and delays functional recovery in a middle-aged rodent model of spinal cord injury

Fig. 4

Aged animals show diminished motor function recovery after injury. a At 1 dpi, no difference in performance in BBB scores were observed in injured rats. At all other time points (7, 14, 21, and 28 dpi), 12-month-old injured rats (n = 17) showed significantly reduced BBB scores compared to 3-month-old rats (n = 18), indicating significantly impaired recovery to injury. b Aged animals show impaired ability to plantar step and complete footprint analysis task. Twelve-month-old rats (n = 17) show significantly diminished ability to plantar step in order to complete the footprint analysis task compared to 3-month-old rats (n = 14), indicating a diminished ability to take steps or strides. c At 28 dpi, toe spread analysis showed a trend in 12-month-old rats (n = 7) toward narrower toe spread compared to 3-month-old rats (n = 5). d 12-month-old rats (n = 7) showed significantly decreased stride length compared to 3-month-old rats (n = 5). *p < 0.05, **p < 0.005, ***p < 0.0005, ****p < 0.0001. Bars represent mean ± SEM

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Journal of Neuroinflammation

ISSN: 1742-2094