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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Age exacerbates microglial activation, oxidative stress, inflammatory and NOX2 gene expression, and delays functional recovery in a middle-aged rodent model of spinal cord injury

Fig. 5

Aged rats have significantly great lesion volume rostral and caudal to the lesion. a Quantitative analysis of tissue stained with H&E reveals that at 30 dpi, 12-month-old rats show an increased lesion volume compared to 3-month-old rats both rostral and caudal to the injury epicenter, suggesting that aged rats have an increased volume and length of lesion compared to young. Lesion volume histogram shows the pattern of lesion spread from the epicenter. b Lesion volume rostral to the epicenter (0–180 μm) was significantly greater in 12-month-old rats compared to 3-month-old rats. c No significant difference was found in lesion volume at injury epicenter (360–540 μm). d Lesion volume caudal to the epicenter (720–900 μm) was significantly greater in 12-month-old aged rats compared to 3-month-old rats. e Photos depict sections of the spinal cord at each segment through the lesion from both 3- and 12-month-old rats. Rostral image is from a 120-μm section, epicenter image is from a 400-μm section, and caudal image is from a 820-μm section. Size bar = 3 mm. N = 6/group. **p < 0.005, ****p < 0.0001. Bars represent mean ± SEM

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